Pharmacology: Pharmacodynamics: Corticoids suppress the inflammatory response to a variety of agents and they probably delay or slow healing.
Since corticosteroids may inhibit the body's defense mechanism against infection, a concomitant antimicrobial drug may be used when this inhibition is considered to be clinically significant in a particular case.
The anti-infective component in the combination is included to provide action against specific organism susceptible to it.
Neomycin sulfate is considered active against the following microorganisms: Staphylococcus aureus, Corynebacterium diphtheriae, Streptococcus viridans, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Aerobacter aerogenes, and Haemophilus influenza.
Polymyxin B Sulfate is considered active against the following microorganisms: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Klebsiella pneumoniae and Koch-Weeks bacillus.
Pharmacokinetics: When a decision to administer both a corticoid and an antimicrobial is made the administration of such drugs in combination has the advantage of greater patient compliance and convenience, with the added assurance that the appropriate dosage of both drugs is administered, plus assured compatibility of ingredients when types of drugs are in the same formulation and, particularly, that the correct volume of the drug is delivered and retained.
The relative potency of corticosteroids depends on the molecule structure, concentration and release from the vehicle.