This drug may cause drowsiness, if affected, do not drive or operate machinery.
Symptoms: Sedation, apnoea, arrhythmias, CV collapse, cyanosis, decreased mental alertness; paradoxical excitation of the CNS (children), hallucinations, insomnia, tremors; blurred vision, dizziness, hypotension, tinnitus; dry mouth, fixed dilated pupils, flushing, gastrointestinal symptoms, and hyperthermia. Management: Symptomatic and supportive treatment. Immediately induce vomiting. Administer saline cathartics (e.g. milk of magnesia) to dilute gastrointestinal contents. May give vasopressors to treat hypotension.
Increased sedative effects with opioid analgesics, sedatives, and hypnotics. Increased anticholinergic activity with TCAs. Potentially Fatal: Increased anticholinergic effects with MAOIs.
Increased CNS depression with alcohol.
Description: Dexchlorpheniramine is the dextrorotatory isomer of chlorphenamine with approximately twice its activity by weight. It competes with free histamine for binding at the H1-receptor sites on effector cells in the gastrointestinal tract, respiratory tract, and the blood vessels. Pharmacokinetics: Absorption: Time to peak plasma concentration: Approx 3 hours. Metabolism: Metabolised in the liver. Excretion: Via urine. Elimination half-life: 20-30 hours.
R06AB02 - dexchlorpheniramine ; Belongs to the class of substituted alkylamines used as systemic antihistamines.
Anon. Chlorpheniramine. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 03/07/2020.Anon. Dexchlorpheniramine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 03/07/2020.Bayer New Zealand Limited. Polaramine Tablets, Film Coated and Syrup Data Sheet 2 December 2017. Medsafe. http://www.medsafe.govt.nz/. Accessed 03/07/2020.Buckingham R (ed). Chlorphenamine Maleate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/07/2020.Dexchloramine Syrup (Duopharma Manufacturing [Bangi] Sdn Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my/. Accessed 22/07/2020.Dexchlorpheniramine Maleate Solution (Foxland Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 03/07/2020.