Dexetimide


Concise Prescribing Info
Indications/Uses
Alleviate drug-induced extrapyramidal symptoms.
Dosage/Direction for Use
Adult : PO 0.5-1 mg once daily.
Dosage Details
Oral
Drug-induced extrapyramidal symptoms
Adult: 0.5-1 mg once daily. May also be given via IM admin.
Renal Impairment
Mild to moderate: reduce initial dose; severe: avoid use.
Hepatic Impairment
Mild to moderate: reduce initial dose; severe: avoid use.
Contraindications
Prostatic hyperplasia, paralytic ileus, pylori stenosis, close-angle glaucoma, and myasthenia gravis (except in decreasing muscarinic side-effects of anticholinesterases).
Special Precautions
Child and elderly, pregnancy and lactation, Down's syndrome, gastroesophageal reflux disease, diarrhoea, ulcerative colitis, acute MI, hypertension, hyperthyroidism, cardiac insufficiency and surgery; pyrexia. Patients with arteriosclerosis or history of drug idiosyncrasy may produce severe mental disturbances, excitement, nausea and vomiting; starting with small initial doses with gradual increase may be necessary. Increases in dosage and treatment withdrawal should be gradual.
Adverse Reactions
Dryness of the mouth, difficulty in swallowing and talking; thirst and reduced bronchial secretions. Mydriasis with cycloplegia and photophobia. Flushing, dryness of the skin, transient bradycardia followed by tachycardia with palpitations and arrhythmias; difficulty in micturition. Reduction in tone and motility of GI tract leading to constipation. Drowsiness; slight transient hypotension following parenteral administration.
Overdosage
Overdosage symptoms usually occur within 4 hr. Common symptoms are abdominal pain, nausea, vomiting, lethargy, drowsiness, headache, nystagmus, tinnitus and ataxia. Rarely, moderate or severe symptoms include GI bleed, hypotension, hypothermia, metabolic acidosis, seizures, impaired renal function, coma, adult respiratory distress syndrome and transient episodes of apnea. Treatment is symptomatic, and there is no specific antidote. Drink water to minimize GI upset if <50 mg/kg dexibuprofen consumed. Activated charcoal should be admin in more severe overdose. Empty the stomach by emesis if within 60 min of ingestion. Gastric lavage to be attempted only if a potentially life-threatening amount of the drug have been consumed and within 60 min of ingestion. Forced diuresis, haemodialysis or haemoperfusion are unlikely to be helpful.
Drug Interactions
Effects enhanced by the concomitant admin of other drugs with antimuscarinic properties eg, amantadine, antihistamines, phenothiazine antipsychotics, and tricyclic antidepressants. Effects also enhanced by MAOIs. Dexetimide may affect the absorption of other drugs. Antimuscarinics and parasympathomimetics may counteract each others effects.
Action
Description: Dexetimide is a tertiary antimuscarinic having similar actions with benzhexol (trihexyphenidyl). It has been used to alleviate drug-induced extrapyramidal syndrome. Like other antimuscarinics, it is of no value against tardive dyskinesia.
Disclaimer: This information is independently developed by MIMS based on Dexetimide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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