Dexilant

Dexilant

dexlansoprazole

Manufacturer:

Takeda

Distributor:

DKSH
Concise Prescribing Info
Contents
Dexlansoprazole
Indications/Uses
Healing of erosive esophagitis (EE). Maintenance of healed EE & relief of heartburn. Heartburn associated w/ symptomatic non-erosive GERD.
Dosage/Direction for Use
Patient ≥12 yr Healing of EE 60 mg once daily for up to 8 wk. Maintenance of healed EE & relief of heartburn Adult 30 mg once daily for up to 6 mth. Adolescent 12-17 yr 30 mg once daily for up to 4 mth. Patient ≥12 yr Symptomatic non-erosive GERD 30 mg once daily for 4 wk.
Administration
May be taken with or without food: Swallow whole, do not chew. For patients w/ swallowing difficulties, open cap & empty contents in 20 mL water. The dispersion may be administered in an oral syringe or via a nasogastric tube (>16 French).
Contraindications
Special Precautions
Gastric malignancy. Increased risk of Clostridium difficile-associated diarrhea; osteoporosis-related hip, wrist or spine fractures. Subacute cutaneous lupus erythematosus. Hypomagnesemia may lead to hypocalcemia &/or hypokalemia. Vit B12 malabsorption due to long-term therapy (>3 yr). Concomitant use w/ high-dose methotrexate; digoxin; drugs causing hypomagnesemia eg, diuretics. Long-term use. Discontinue use at least 5 days prior to chromogranin A measurements. Severe hepatic impairment. Pregnancy & lactation. Childn <12 yr.
Adverse Reactions
Diarrhea, abdominal pain, nausea, upper resp tract infection, vomiting, flatulence, headache.
Drug Interactions
Decreased systemic conc of HIV PIs eg, atazanavir, nelfinavir. Interfered w/ absorption of ampicillin esters, digoxin, Fe salts, ketoconazole. Increased INR & prothrombin time w/ warfarin. Increased whole blood levels of tacrolimus. Elevated & prolonged serum levels of methotrexate &/or hydroxymethotrexate.
ATC Classification
A02BC06 - dexlansoprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Presentation/Packing
Form
Dexilant DR cap 60 mg
Packing/Price
14's;7's
Form
Dexilant DR cap 30 mg
Packing/Price
14's;7's
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