Discontinue use if hypersensitivity reaction occurs. Not recommended in patients w/ established CV disease (eg, CHF, established ischemic heart disease, peripheral arterial disease) or uncontrolled HTN, or significant risk factors eg, hyperlipidaemia, DM & smoking; serious arteriothrombotic events (eg, chest pain, shortness of breath, weakness, slurring of speech). Stevens-Johnson syndrome & toxic epidermal necrolysis. High-dose & long-term use. Avoid contact w/ eyes or mucous membranes & application to large skin areas. Not recommended during pregnancy.