Discontinue use at 1st appearance of skin rash or other sign of hypersensitivity or if GI bleeding or ulceration occurs. GI disorders, history of GI ulceration, ulcerative colitis or Crohn's disease; history of serious GI events, smoking, alcoholism. Increased risk of serious CV events eg, MI; patients w/ CV disease or risk of CV event; HTN; fluid retention or heart failure. Exfoliative dermatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome. May mask signs & symptoms of infection. Concurrent use of aspirin. Severe hepatic impairment. Not recommended during pregnancy & lactation. Not suitable for childn. Elderly.