Hypersensitivity. Discontinue use if rash, GI bleeding or ulceration occur. GI disorders, history of gastric or intestinaI ulceration, ulcerative colitis or Crohn's disease; history of serious GI events & other risk factors associated w/ PUD eg, smoking, alcoholism. Not recommended in patients w/ established CV disease (eg, CHF, established ischemic heart disease, peripheral arterial disease) or uncontrolled HTN, or significant risk factors eg, hyperlipidaemia, DM, smoking. Patients w/ CV disease or risk of CV event; serious arteriothrombotic events eg, chest pain, shortness of breath, weakness, slurring of speech; HTN; fluid retention or heart failure. Stevens-Johnson syndrome & toxic epidermal necrolysis. May mask signs & symptoms of infections. High dose & long-term use. Patients on antihypertensive & corticosteroid therapy. Severe hepatic impairment. Avoid use during late pregnancy. Not recommended during lactation. Not recommended in childn & adolescents <14 yr. Elderly.