Diethylstilbestrol


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Palliation of malignant breast neoplasms in postmenopausal women 10-20 mg/day. Advanced prostatic carcinoma 1-3 mg/day. Vaginal Menopausal atrophic vaginitis As pessary: 1 mg/day.
Dosage Details
Oral
Palliative treatment of malignant breast neoplasms in postmenopausal women
Adult: 10-20 mg daily.

Oral
Advanced prostatic carcinoma
Adult: 1-3 mg daily.

Vaginal
Menopausal atrophic vaginitis
Adult: 1 mg daily as pessaries.
Renal Impairment
Use with caution.
Hepatic Impairment
Use with caution.
Contraindications
Pregnancy, thromboembolic disease, porphyria; breast cancer (with exceptions).
Special Precautions
CV disease; hepatic and renal impairment.
Adverse Reactions
GI disturbances, CV and CNS side effects, jaundice, impotence. Feminization, impotence and gynaecomastia in men. Withdrawal and breakthrough bleeding, irregular menses, amenorrhoea in women. Hypercalcaemia, chloasma, keratoconus, contact lenses intolerance, altered carbohydrate metabolism, loss of diabetic control.
Drug Interactions
Anticoagulants, liver enzyme inducers, corticosteroids.
Lab Interference
Elevated liver function tests.
Action
Description: Diethylstilbestrol is a synthetic nonsteroidal oestrogen with effects similar to natural oestrogens. It inhibits luteinising hormone secretion by the pituitary, thereby inhibiting testosterone secretion.
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract.
Metabolism: Slowly metabolised in the liver.
Excretion: Excreted in the urine and faeces, mainly as the glucuronide.
Disclaimer: This information is independently developed by MIMS based on Diethylstilbestrol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in