Diphenylpyraline hydrochloride


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Allergic conditions; Pruritic skin disorders Up to 6 mg/day in 3-4 divided doses.
Dosage Details
Oral
Allergic conditions, Pruritic skin disorders
Adult: Up to 6 mg daily in 3-4 divided doses.
Contraindications
Severe liver disease; avoid alcohol; premature infants or full-term neonates.
Special Precautions
May impair ability to drive and operate machinery. Angle-closure glaucoma, urinary retention, prostatic hypertrophy or pyloroduodenal obstruction; epilepsy; hepatic impairment. Elderly. Pregnancy and lactation.
Adverse Reactions
Sedation; antimuscarinic effects, CNS depression and disturbances; occasionally, paradoxical CNS stimulation esp in child; psychomotor impairment; headache; palpitations and arrhythmias. Convulsions, sweating, myalgia, paraesthesias, extrapyramidal symptoms, tremor, sleep and GI disturbances, hypersensitivity reactions and blood disorders; tinnitus, hypotension; hair loss.
Drug Interactions
Enhance effects of CNS depressants eg, alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Atropine, tricyclic antidepressants (TCAs), MAOIs. Can mask signs of ototoxicity caused by aminoglycosides. May antagonise the action of betahistine. Increased risk of seizure when used with bupropion. Concurrent use with mefloquine may lead to prolongation of the QT interval.
Lab Interference
May interfere with skin testing.
Action
Description: Diphenylpyraline, a piperidine derivative, is an antihistamine with antimuscarinic and significant sedative properties.
Disclaimer: This information is independently developed by MIMS based on Diphenylpyraline hydrochloride from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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