Disodium hydrogen citrate

Generic Medicine Info
Indications and Dosage
Urine alkalinisation
Adult: 15-30 mL bid-tid.
Child: <7 yr 2 mL tid; 7-12 yr 5 mL tid.
Hyperosmolar states, HTN, oedema.
Special Precautions
Hypocalcaemia, hypoventilatory states, alkalosis. Renal disease. Childn including neonates. Pregnancy and lactation.
Adverse Reactions
Mild diuresis, stomach cramps, flatulence, diarrhoea, GI ulceration, hypokalaemia, metabolic alkalosis, tiredness, dyspnoea, anxiety, mood swings.
Symptom: Metabolic alkalosis. Management: Symptomatic and supportive treatment.
Drug Interactions
Enhances elimination of salicylates and barbiturates. May increase the half-life of quinidine, ephedrine, pseudoephedrine. Additive effect w/ Na retention caused by corticosteroids. Potentiates renal excretion of tetracycline. Hypochloraemic alkalosis may occur w/ concomitant K-depleting diuretics.
Food Interaction
Avoid alcohol.
Lab Interference
May interfere w/ urine ketone test.
Description: Disodium hydrogen citrate is metabolised to bicarbonate, which then increases urinary pH by increasing the excretion of free bicarbonate ions, thereby increasing the solubility of cystine in the urine and the ionization of uric acid to more soluble urate ion.
Onset: <1 min.
Duration: 4-6 hr.
MIMS Class
Other Drugs Acting on the Genito-Urinary System
Buckingham R (ed). Bicarbonate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 27/04/2016 .

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