Disodium hydrogen citrate


Concise Prescribing Info
Indications/Uses
Urine alkalinisation
Dosage/Direction for Use
Adult : PO 15-30 mL bid-tid.
Dosage Details
Oral
Urine alkalinisation
Adult: 15-30 mL bid-tid.
Child: <7 yr 2 mL tid; 7-12 yr 5 mL tid.
Contraindications
Hyperosmolar states, HTN, oedema.
Special Precautions
Hypocalcaemia, hypoventilatory states, alkalosis. Renal disease. Childn including neonates. Pregnancy and lactation.
Adverse Reactions
Mild diuresis, stomach cramps, flatulence, diarrhoea, GI ulceration, hypokalaemia, metabolic alkalosis, tiredness, dyspnoea, anxiety, mood swings.
Overdosage
Symptom: Metabolic alkalosis. Management: Symptomatic and supportive treatment.
Drug Interactions
Enhances elimination of salicylates and barbiturates. May increase the half-life of quinidine, ephedrine, pseudoephedrine. Additive effect w/ Na retention caused by corticosteroids. Potentiates renal excretion of tetracycline. Hypochloraemic alkalosis may occur w/ concomitant K-depleting diuretics.
Food Interaction
Avoid alcohol.
Lab Interference
May interfere w/ urine ketone test.
Action
Description: Disodium hydrogen citrate is metabolised to bicarbonate, which then increases urinary pH by increasing the excretion of free bicarbonate ions, thereby increasing the solubility of cystine in the urine and the ionization of uric acid to more soluble urate ion.
Onset: <1 min.
Duration: 4-6 hr.
References
Buckingham R (ed). Bicarbonate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 27/04/2016 .

Disclaimer: This information is independently developed by MIMS based on Disodium hydrogen citrate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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