No interactions between Divigel and other medicines have been reported.
There are some indications that estrogens may reduce the effects of antihypertensive, anticoagulant and antidiabetic drugs. Concomitant treatment with potent inducers of liver enzymes (e.g. barbiturates, carbamazepine, griseofulvin and rifampicin) may reduce the plasma levels of estradiol. The significance of these interactions in transdermal application has not been elucidated.