History of atopy or severe anaphylactic reaction to variety of allergens. Patients w/ CV diseases & hypotension; severe peripheral circulatory disturbance/disorders eg, severe forms of Raynaud's disease or syndrome; asthma; spontaneous hypoglycaemia or w/ labile diabetes; muscle weakness; active intraocular inflammation, predisposing risk factors for uveitis; choroidal detachment. Aphakic patients, pseudophakic patients w/ torn posterior lens cap or anterior chamber lenses, known risk factors for macular edema. May mask signs of acute hypoglycaemia & hyperthyroidism. Possibility of permanent change in eye colour, periorbital &/or eyelid skin darkening; increase length, thickness, pigmentation &/or number of lashes. Not recommended w/ another topical β-blockers. Concomitant use w/ prostaglandin analogues; surgical anaesth. May affect ability to drive or use machines. Not to be used during pregnancy. Lactation. Childn & adolescents <18 yr.