Duovent

Duovent

ipratropium + fenoterol

Manufacturer:

Boehringer Ingelheim

Distributor:

DKSH
Concise Prescribing Info
Contents
Per 4 mL Ipratropium Br 0.5 mg, fenoterol HBr 1.25 mg
Indications/Uses
Symptomatic prevention & treatment of chronic obstructive airway disorders w/ reversible airflow limitation eg, bronchial asthma & especially chronic bronchitis w/ or w/o emphysema. Concomitant anti-inflammatory therapy considered for patients w/ bronchial asthma & steroid-responsive COPD.
Dosage/Direction for Use
Adult, elderly & adolescent >12 yr Acute asthma episodes 1 unit-dose vial. Very severe cases 2 unit-dose vials.
Contraindications
Hypersensitivity to fenoterol HBr or atropine-like substances. Hypertrophic obstructive cardiomyopathy, tachyarrhythmia.
Special Precautions
Hypersensitivity. Discontinue immediately if paradoxical bronchospasm occurs. Patients predisposed to narrow-angle glaucoma. Insufficiently controlled DM, recent MI, severe organic heart or vascular disorders, hyperthyroidism, phaeochromocytoma, pre-existing urinary outflow tract obstruction eg, prostatic hyperplasia or bladder-neck obstruction; severe CV disease eg, ischaemic heart disease, arrhythmia or severe heart failure; hypokalaemia; cystic fibrosis; acute, rapidly worsening dyspnoea. May lead to positive doping test. Prolonged use. Concomitant use w/ other sympathomimetic bronchodilators. May affect ability to drive & use machines. Pregnancy & lactation. Not recommended in childn ≤12 yr.
Adverse Reactions
Cough, dry mouth, headache, tremor, pharyngitis, nausea, dizziness, dysphonia, tachycardia, palpitations, vomiting, increased systolic BP, nervousness.
Drug Interactions
Enhanced bronchodilatatory effects w/ other β-adrenergics, anticholinergics, xanthine derivatives eg, theophylline. Potentially serious reduction in bronchodilatation w/ β-blockers. Increased β2-agonist induced hypokalaemia w/ xanthine derivatives, corticosteroids, diuretics. Increased susceptibility to arrhythmias w/ digoxin. Enhanced β-adrenergic agonists action w/ MAOIs or TCAs. Increased susceptibility on CV effects of β-agonists w/ halogenated hydrocarbon anaesth eg, halothane, trichloroethylene, enflurane.
ATC Classification
R03AL01 - fenoterol and ipratropium bromide ; Belongs to the class of combination of adrenergics with anticholinergics, that may also include a corticosteroid. Used in the treatment of obstructive airway diseases.
Presentation/Packing
Form
Duovent inhalant (unit-dose vial)
Packing/Price
4 mL x 60 × 1's
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