The daily dosage should be adapted on individual basis.
The following serves as a guideline: Chronic Constipation: Starting Dose (For 3 Days): Adults and Children ≥15 years: 15-45 mL. Children 7-14 years: 15 mL, 1-6 years: 5-10 mL. Infants: 5 mL.
Maintenance Dose: Adults and Children ≥15 years: 15-30 mL. Children 7-14 years: 10-15 mL, 1-6 years: 5-10 mL. Infants: 5 mL.
As a rule, the dosage can be decreased after a couple of days to serve patients' needs. The dosage should preferably be taken in one time during breakfast. Onset of the clinical effect may take a couple of days. This is inherent to the mode of action of lactulose. Higher dosages can be considered if a positive response has not occurred after the first 2 days.
Pre-Coma and Coma Hepaticum: Starting Dose: 30-45 mL 3 times daily.
Maintenance Dose: Should be adapted as such the soft stools are produced maximally 2-3 times/day. The pH of the stools should be preferably 5-5.5.
Medical Benefit of the Stools: These are the same as in constipation. This indication can be included in constipation.