Known hypersensitivity to the active substance or to any of the excipients.
Known or suspected progestogen dependent neoplasms (e.g. meningioma).
Undiagnosed vaginal bleeding.
Contraindications which are related to the use of estrogen when Duphaston is used in combination with estrogen (see also the contraindication in the product information of the estrogen preparation).
Treatment for luteal support as part of an Assisted Reproductive Technology (ART) treatment should be discontinued upon diagnosis of abortion or miscarriage.