Always take Duphaston exactly as the doctor has prescribed. If there are any questions, contact the doctor or pharmacist.
If the patient forgets to take the tablet(s), do not take a double dose to compensate for it. If the patient requires further information, please ask the doctor or pharmacist for advice.
For hormone replacement therapy: In combination with continuous oestrogen therapy, take one tablet daily for 14 consecutive days of a 28 day cycle.
In combination with cyclical oestrogen therapy, take one tablet daily during the last 12 to 14 days of oestrogen therapy.
For doctors: If endometrial biopsies or ultrasound reveal inadequate progestational response, 20 mg dydrogesterone should be prescribed.
If the patient is not sure what type of oestrogen therapy, talk to the doctor before taking Duphaston.
Posology for specific indications: Dysmenorrhoea (painful menstruation): Take one tablet twice daily from day 5 to day 25 of the cycle.
Endometriosis (abnormal growth of uterine tissues outside the uterus): Take one tablet two or three times daily from day 5 to day 25 of the cycle or continuously (as prescribed by the doctor).
Dysfunctional bleeding (to stop bleeding): Take one tablet twice daily for five to seven days.
Dysfunctional bleeding (to prevent bleeding): Take one tablet twice daily from day 11 to day 25 of the cycle.
Amenorrhoea (cessation of menstruation): The doctor should prescribe an oestrogen along with Duphaston. Then take the oestrogen once daily from day 1 to day 25 of the cycle, together with one tablet of dydrogesterone twice daily from day 11 to day 25 of the cycle.
Premenstrual syndrome: Take one tablet twice daily from day 11 to day 25 of the cycle.
Irregular cycles: Take one tablet twice daily from day 11 to day 25 of the cycle.
Threatened abortion: Take four tablets at once, then one tablet every eight hours until symptoms abate.
Habitual abortion: Take one tablet twice daily until the twentieth week of pregnancy.
Infertility due to luteal (yellow body) insufficiency: Take one tablet daily from day 14 to 25 of the cycle. Continue the treatment for at least six consecutive cycles. In addition, it is advisable to continue treatment for the first few months of pregnancy as described under "Habitual abortion". If the patient is uncertain about how long to continue the treatment, talk to the doctor.
Luteal support as part of an Assisted Reproductive Technology (ART) treatment: Take one tablet three times daily (30mg daily) starting at the day of oocyte retrieval and continuing for 10 weeks if pregnancy is confirmed.
Duphaston is not recommended for use in children below age 18 due to insufficient data on safety and efficacy.