Ebixa

Ebixa

memantine

Manufacturer:

Lundbeck

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Memantine HCl
Indications/Uses
Moderate to severe Alzheimer's disease.
Dosage/Direction for Use
Adult Initially 5 mg daily on the 1st wk, 10 mg daily on the 2nd wk, then 15 mg daily on the 3rd wk. Continue treatment from 4th wk thereafter w/ maintenance dose: 20 mg daily. Max: 20 mg once daily. Elderly >65 yr 20 mg daily. Moderate renal impairment (CrCl 30-49 mL/min) 10 mg daily, may be increased to 20 mg daily, severe renal impairment (CrCl 5-29 mL/min) 10 mg daily.
Administration
May be taken with or without food: Take at the same time each day.
Contraindications
Special Precautions
Epilepsy, history of convulsions or patients w/ predisposing factors for epilepsy. Recent MI, uncompensated CHF, uncontrolled HTN. Careful monitoring of patients w/ factors raising urine pH eg, drastic changes in diet, massive ingestion of alkalising gastric buffers, renal tubulary acidosis or severe UTI w/ Proteus bacteria. Avoid concomitant use w/ N-methyl-D-aspartate antagonists eg, amantadine, ketamine or dextromethorphan. Not recommended in severe hepatic impairment. Moderate to severe renal impairment. May affect ability to drive & use machines. Not to be used during pregnancy & lactation. Not recommended in childn <18 yr.
Adverse Reactions
Drug hypersensitivity; somnolence; dizziness, balance disorders; HTN; dyspnoea; constipation; elevated liver function test; headache.
Drug Interactions
Enhanced effects of L-dopa, dopaminergic agonists, anticholinergics. Reduced effects of barbiturates, neuroleptics. Modified effects of antispasmodic agents, dantrolene or baclofen. Increased plasma levels w/ cimetidine, ranitidine, procainamide, quinidine, quinine, nicotine. Reduced serum level of hydrochlorothiazide. Increased INR w/ warfarin. Avoid use w/ N-methyl-D-aspartate antagonists eg, amantadine, ketamine or dextromethorphan.
ATC Classification
N06DX01 - memantine ; Belongs to the class of other anti-dementia drugs.
Presentation/Packing
Form
Ebixa FC tab 20 mg
Packing/Price
28's
Form
Ebixa FC tab 10 mg
Packing/Price
56's
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