Efexor XR

Efexor XR

venlafaxine

Manufacturer:

Viatris

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Venlafaxine HCl
Indications/Uses
Depression including depression w/ associated anxiety. Generalized anxiety disorder (GAD) including long-term treatment. Social anxiety disorder (SAD or social phobia), panic disorder including prevention of relapse. Prevention of relapse & recurrence of depression.
Dosage/Direction for Use
Major depressive disorder Initially 75 mg once daily, may be increased in 75-mg increments at ≥4 days interval. Dose can be titrated up to 225 mg daily in moderate depression & 375 mg daily in severe depression. GAD Initially 75 mg once daily, may be increased up to max: 225 mg daily. SAD Initially 75 mg once daily. Panic disorder Initially 37.5 mg daily for 7 days, then increased to 75 mg daily. May be further increased up to max: 225 mg daily.
Administration
Should be taken with food: Take at the same time each day. Swallow whole, do not chew/crush/divide/dissolve. Cap may be carefully opened & entire contents sprinkled on a spoonful of applesauce. Swallow drug/food mixt w/o chewing immediately after prep & followed w/ glass of water.
Contraindications
Hypersensitivity. Concomitant use or w/in at least 14 days after discontinuation of MAOIs. Discontinue use for at least 7 days before initiating MAOI.
Special Precautions
Monitor patients for suicide/suicidal thoughts or clinical worsening. Increased risk of bone fractures. NMS-like reactions; sexual dysfunction; hyponatermia; mydriasis; risk factors for QTc prolongation; history of convulsions or bipolar disorder or aggression; patients predisposed to bleeding. Abuse & dependence. Monitor BP, control preexisting HTN in BP or heart rate compromised patients. Measure serum cholesterol in long-term use. Avoid abrupt discontinuation. Not recommended in concomitant use w/ serotonin precursors; wt loss agents. May affect ability to drive & use machines. Renal or hepatic impairment. Pregnancy & lactation. Childn & adolescents <18 yr. Elderly.
Adverse Reactions
Headache, abnormal dreams, decreased libido, dizziness, dry mouth, increased muscle tonus, insomnia, nervousness, paresthesia, sedation, tremor, confusion, depersonalization, asthenia, fatigue, HTN, vasodilatation, palpitations, stress cardiomyopathy, increased serum cholesterol, wt loss, sweating, accommodation abnormality, mydriasis, visual disturbances, abnormal ejaculation/orgasm (males), anorgasmia, erectile dysfunction, menstrual disorders, impaired urination, increased urinary frequency, yawning, decreased appetite, constipation, nausea, vomiting, chills.
Drug Interactions
Severe AR w/ MAOIs. Serotonin syndrome w/ other serotonergic agents eg, triptans, SSRIs, other SNRIs, amphetamines, lithium, sibutramine, fentanyl & its analogues, tramadol, dextromethorphan, tapentadol, meperidine, methadone, pentazocine, St. John's wort; drugs impairing serotonin metabolism eg, linezolid & methylene blue or serotonin precursors eg, tryptophan supplements. Risk of QTc prolongation &/or ventricular arrhythmias w/ some antipsychotics & antibiotics. Decreased AUC & Cmax of indinavir. Increased AUC & Cmax of haloperidol, desipramine. Increased plasma conc w/ ketoconazole, metoprolol. Increased AUC of risperidone. Reduced metabolism w/ CYP2D6 inhibitors. Increased levels w/ CYP3A4 inhibitors. False +ve urine immunoassay screening tests for PCP & amphetamine. CNS-active drugs.
MIMS Class
ATC Classification
N06AX16 - venlafaxine ; Belongs to the class of other antidepressants.
Presentation/Packing
Form
Efexor XR XR cap 150 mg
Packing/Price
28's
Form
Efexor XR XR cap 75 mg
Packing/Price
28's
Form
Efexor XR XR cap 37.5 mg
Packing/Price
7's
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