Eligard

Eligard

leuprorelin

Manufacturer:

Astellas Pharma

Distributor:

DKSH
Concise Prescribing Info
Contents
Leuprorelin acetate
Indications/Uses
Palliative treatment of hormone-dependent advanced prostate cancer. High-risk localized & locally advanced hormone dependent prostate cancer in combination w/ radiation therapy.
Dosage/Direction for Use
SC Adult 7.5 mg every mth; 22.5 mg every 3 mth; 45 mg every 6 mth.
Contraindications
Hypersensitivity to leuprorelin acetate or other GnRH agonist. Patients who previously underwent orchiectomy. Sole treatment in prostate cancer patients w/ spinal cord compression or evidence of spinal metastases. Women & paed patients.
Special Precautions
History of or risk factors for QT prolongation; increased risk of developing MI, sudden cardiac death & stroke; increased risk for fractures owing to osteoporosis; pituitary apoplexy; hyperglycemia & increased risk of developing diabetes; convulsions; ureteral obstruction, spinal cord compression. Closely monitor patients w/ vertebral &/or brain metastases, urinary tract obstruction. Monitor signs & symptoms of CV disease. Periodically monitor blood glucose &/or HbA1c. Transient increased serum conc of testosterone, dihydrotestosterone & acid phosphatase during 1st wk of treatment. Concomitant use w/ drugs prolonging QT interval. May affect ability to drive & use machines. Childn <18 yr.
Adverse Reactions
Hot flashes; ecchymoses, erythema; fatigue, inj site burning & paraesthesia. Nasopharyngitis; nausea, diarrhea, gastroenteritis/colitis; pruritus, night sweats; arthralgia, limb pain, myalgia, rigors, weakness; urinary infrequency, difficulty in micturation, dysuria, nocturia, oliguria; breast tenderness & hypertrophy, testicular atrophy & pain infertility, erectile dysfunction, reduced penis size; malaise, inj site pain, bruising & stinging; hematology changes, anaemia; increased blood creatinine phosphokinase, prolonged coagulation time.
ATC Classification
L02AE02 - leuprorelin ; Belongs to the class of gonadotropin releasing hormone analogues. Used in endocrine therapy.
Presentation/Packing
Form
Eligard powd for inj (pre-filled syringe + solvent) 22.5 mg
Packing/Price
1's
Form
Eligard powd for inj (pre-filled syringe + solvent) 45 mg
Packing/Price
1's
Form
Eligard powd for inj (pre-filled syringe + solvent) 7.5 mg
Packing/Price
1's
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