Eliglustat - oral


Patient Medicine Information
Why do I need this medicine?
Eliglustat is used as an enzyme replacement therapy to treat Gaucher disease type 1 (an inherited disorder where the body has insufficient enzyme necessary to break down fatty chemicals causing liver and spleen enlargement).

This medicine is intended to be used by patients whose body breaks down this medicine at normal speed (known as intermediate or extensive metabolisers) or at slow speed (known as poor metabolisers).
How do I take this medicine?
Take this medicine exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day. Swallow it whole. Do not divide, chew or crush the capsule.

Eliglustat must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
If you missed a dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have heart disease, including irregular heartbeat, as Eliglustat may not be suitable for you.

Genetic traits can affect an individual’s response to this medicine. Your doctor needs to perform genetic testing before giving you this medicine to know if it is suitable for you.

Do not take Eliglustat if you are a CYP2D6 ultrarapid metaboliser or if your CYP2D6 metaboliser status is not determined.

Alert your doctor if you have liver or kidney disease. Your doctor will assess whether this medicine is suitable for you based on your CYP2D6 metaboliser status.

Do not take this medicine if you are a CYP2D6 intermediate or extensive metaboliser and taking a strong or moderate CYP2D6 inhibitor together with a strong or moderate CYP3A inhibitor; or if you are a CYP2D6 poor metaboliser taking weak to strong CYP3A inhibitor.

Do not take Eliglustat with medicines used to treat irregular heartbeat.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • liver disease
  • kidney disease
Let your doctor know if you are pregnant or breastfeeding.

Keep your appointment with your doctor. Your doctor may need to perform tests to make sure that your liver, kidney and heart function normally before you take this medicine and thereafter depending on your doctor’s advice.
What side effects could I experience?
Eliglustat may cause any of the following side effects: tiredness, headache, nausea, diarrhoea, pain in the arms, legs, back or stomach.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Eliglustat if you are taking any of these medicines:
  • medicines for irregular heartbeat e.g. quinidine, amiodarone
  • medicines to treat depression e.g. fluoxetine, duloxetine
  • medicines to treat fungal infections e.g. itraconazole, fluconazole, terbinafine 
Inform your doctor if you are taking any of these medicines:
  • medicines to treat TB (lung infection known as tuberculosis) e.g. rifampicin
  • medicines for epilepsy (fits or seizures) e.g. carbamazepine, phenobarbital
  • medicines to treat cancer e.g. topotecan, vincristine
  • St John’s Wort (herbal medicine) 
This list does not include all medicines that may interact with Eliglustat.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid excessive consumption of grapefruit or grapefruit juice (more than 1 litre a day).

Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on eliglustat - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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