Administer carefully to pregnant patients or female of childbearing potential.
Embryonic toxicity may occur when econazole nitrate (10-40 times of skin dosage for men) is administered orally to rats. Similar results occur when econazole nitrate (40-80 times of skin dosage for men) is administered orally to mouse, rabbit and rats.
Safety for use of Endix in pregnancy has not yet been established. It should be given to women who are pregnant or potentially pregnant only when the expected benefits exceed the risks. Especially, do not use in pregnancy within 3 months.
It has not been reported that Endix is excreted in human milk but corticoids, which is absorbed, is systemically excreted in human milk.