Discontinue use if MI, cerebrovascular disorders, arterial or venous thromboembolism (venous thromboembolism or pulmonary embolism), thrombophlebitis or retinal thrombosis are suspected; transient ischemic events, appearance of sudden severe headaches or papillary edema- or retinal hemorrhage-related vision impairments occur. History of depression. Epilepsy, migraine, asthma, cardiac dysfunction. Diabetic patients; patients >35 yr, smokers, w/ risk factors for atherosclerosis. Assess infertility causes prior to treatment. Avoid abrupt discontinuation. May affect ability to drive & use machines. Renal & mild to moderate hepatic dysfunction. 2nd & 3rd trimesters of pregnancy. Not to be used during lactation.