Entacapone - oral

Patient Medicine Information
Why do I need this medicine?
Entacapone is used together with other medicines to treat Parkinson's disease. Parkinson's disease is a disorder that affects movement of a person, causing symptoms such as tremors, muscle stiffness, slowed movement and impaired balance or walking. It is used to improve the medicinal effect of another Parkinson's disease medicine called levodopa.

Entacapone cannot cure Parkinson's disease, but it can improve the quality of life for people who have the disease.
How do I take this medicine?
Take Entacapone exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take Entacapone together with each dose of levodopa.

You may take Entacapone with or without food. Try to take it at the same time each day.

Entacapone must be taken regularly for it to be effective. Continue taking Entacapone even when you feel better. Do not stop taking it unless instructed otherwise, as stopping it suddenly could worsen your condition.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • liver disease
  • adrenal gland tumour called phaeochromocytoma
  • history of neuroleptic malignant syndrome (a neurological disorder associated with the use of medicines for mood disorder, characterised by muscle rigidity, fever and blood pressure changes)
  • history of non-traumatic rhabdomyolysis (abnormal muscle breakdown that can cause kidney damage)
as Entacapone may not be suitable for you.

DO NOT take Entacapone with medicines used to treat depression, such as isocarboxazid, phenelzine and tranylcypromine.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • bile duct obstruction
  • kidney disease
  • heart disease
  • tardive dyskinesia (a condition which causes uncontrollable twitching movements of the mouth, tongue and limbs)
Let your doctor know if you are pregnant or breastfeeding.
What side effects could I experience?
Entacapone may cause drowsiness or dizziness. Entacapone may also cause you to suddenly fall asleep during your daily activities such as eating and watching television. You may not feel drowsy before you fall asleep. If affected, do not drive or take part in any activity in which you need to be alert.

Entacapone may cause your blood pressure to fall suddenly when you get up from a sitting or lying down position and you may feel giddy. To minimise this problem, stand up slowly.

Other side effects include any of the following: nausea, diarrhoea, vomiting, constipation, abdominal pain and dry mouth. These side effects are common especially when you have just started taking Entacapone.

Let your doctor know if you experience:
  • confusion and hallucinations (seeing, hearing or feeling things that are not existent)
  • unusual changes in mood or behaviour (being too depressed, agitated, or having compulsive and impulsive behaviour)
  • uncontrollable movements such as twitching or jerking
Entacapone may also turn your urine an orange-brown colour. This is harmless, do not be alarmed.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Entacapone with medicines used to treat depression e.g. isocarboxazid, phenelzine and tranylcypromine.

Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for the heart or blood pressure e.g. adrenaline, methyldopa
  • warfarin (blood-thinning medicine)
  • iron pills
If you are taking iron pills, do not take them together with Entacapone. Take them at least 2-3 hours before or after you have taken Entacapone.

This list does not include all medicines that may interact with Entacapone.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on entacapone - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in