Epalrestat


Concise Prescribing Info
Indications/Uses
Diabetic neuropathy.
Dosage/Direction for Use
Adult : PO 50 mg tid.
Dosage Details
Oral
Diabetic neuropathy
Adult: 50 mg tid.
Action
Description: Epalrestat inhibits aldose reductase enzyme which catalyses the conversion of glucose to sorbitol. Accumulation of sorbitol in certain cells occurs only in conditions of hyperglycaemia and resulting in hyperosmotic effect which may be involved in pathogenesis of some diabetic complications. Aldose reducatse inhibitors have no effect on blood-glucose concentrations.
MIMS Class
References
Buckingham R (ed). Epalrestat. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/09/2014.

Disclaimer: This information is independently developed by MIMS based on Epalrestat from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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