Symptoms: In mild to moderate overdose, patients may present with sedation, ataxia, slurred speech, nystagmus, movement disorders, and gastrointestinal upset.
In more severe cases, patients may present with mild hypotension and profound central nervous system depression requiring intubation.
Treatment: Treatment of gabapentin exposure is largely supportive in nature with careful attention to airway protection in severe cases.
Although gabapentin can be removed by hemodialysis, based on prior experience it is usually not required. However, in patients with severe renal impairment, hemodialysis may be indicated.