Bleeding diatheses, thrombocytopenia; thromboembolic events; potential risk of osteoporosis. Dorsogluteal inj site due to proximity of underlying sciatic nerve. Interfered Ab-based estradiol assays. Concomitant use w/ anticoagulants. May affect ability to drive & use machines. Mild to moderate hepatic impairment. Severe renal impairment (CrCl <30 mL/min). Women of childbearing potential should use effective contraception. Not to be used during pregnancy & lactation. Not to be used in neonates. Avoid use in childn <2 yr. Not recommended in childn or adolescents.