Special precautions for disposal and other handling: Anidulafungin must be reconstituted with sterile water for injection and subsequently diluted with ONLY 9 mg/mL (0.9%) sodium chloride for infusion or 50 mg/mL (5%) glucose for infusion. The compatibility of reconstituted anidulafungin with intravenous substances, additives, or medications other than 9 mg/mL (0.9%) sodium chloride for infusion or 50 mg/mL (5%) glucose for infusion has not been established.
Reconstitution of Water for Injection Presentation: Aseptically reconstitute each vial with 30 mL sterile water for injection to provide a concentration of 3.33 mg/mL. The reconstitution time can be up to 5 minutes.
The reconstituted solution may be stored at up to 25°C for 24 hours.
Dilution and Infusion of Water for Injection Presentation: Aseptically transfer the contents of the reconstituted vial(s) into an IV bag (or bottle) containing either 9 mg/mL (0.9%) sodium chloride for infusion or 50 mg/mL (5%) glucose for infusion to obtain the appropriate anidulafungin concentration. The table as follows provides the volumes required for each dose. (See Table 3.)
Click on icon to see table/diagram/image
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. If particulate matter or discoloration are identified, discard the solution.
The rate of infusion should not exceed 1.1 mg/minute (see Precautions and Adverse Reactions). The rate of infusion is equivalent to 1.4 mL/min for the 100 mg and 200 mg doses.
For single use only. Waste materials should be disposed of in accordance with local requirements.
Incompatibilities: This medicinal product must not be mixed or co-administered with other medicinal products or electrolytes except those mentioned previously.