Eritrotex Dosage/Direction for Use





Averroes Pharma
Full Prescribing Info
Dosage/Direction for Use
Erythromycin Lactobionate injection administered by Intravenous.
Adults: The usual adult dose is the equivalent of 25-50 mg/kg per day in divided doses of Erythromycin, by intravenous infusion every 6 hours, or the equivalent of 1 to 2 g of Erythromycin daily by intermittent intravenous infusion over 20 to 60 minutes every 6 hours or by infusion over 24 hours. The equivalent of 4 gram daily has been recommended for severe infections.
Small volume intravenous infusion, minimum volume 100 ml, is the preferred method so as to minimise venous irritation.
Children: 25-50 mg per kg by intravenous injection, daily in divided doses.
Elderly: Use adult dosage with care, taking into consideration any impairments in liver or biliary functions.
Patients with impaired hepatic function: In the presence of normal hepatic function, Erythromycin is concentrated in the liver and excreted in the bile. Although the effect of hepatic dysfunction on the excretion of Erythromycin and its half-life in such patients is not known, caution should be exercised in administering the antibiotic in such cases.
Patients with impaired renal function: The low proportion of renal excretion would suggest that dosage modification in patients with impaired renal function may not be necessary. In severely impaired patients however, toxicity has been reported and dosage adjustment in these cases may be warranted.
Instruction for use: Intravenous administration of Erythromycin is suitable to patients who are unable to tolerate oral medication or when it is necessary to produce a high blood concentration to control severe infections. Oral administration should replace parenteral administration as soon as practicable. Due to the local irritative effects of Erythromycin as well as reports of QT interval prolongation and ventricular arrhythmias (some of which have been fatal) being associated with elevated serum concentrations of Erythromycin, the drug must not be administered rapidly by direct intravenous injection (intravenous push).
For continuous intravenous infusion the concentrated solution should be diluted to a concentration of 1 mg per ml. If required, solution strengths up to 5 mg/ml (0.5% solution) may be used, but should not be exceeded. Higher concentrations may result in pain along the vein. Bolus injection is not recommended.
For intermittent intravenous infusion the appropriate daily dose can be given as 4 doses once every 6 hours. The Erythromycin concentration should not exceed 5mg per ml and the infusion should be administered over 60 minutes, as a rapid infusion is more likely to be associated with arrhythmias or hypotension. A longer period of infusion should be used in patients with risk factors or previous evidence of arrhythmias. Not less than 100ml of diluent should be used for preparing intermittent intravenous solutions.
Intravenous therapy should be replaced by oral administration at the appropriate time.
Incompatibilities: Erythromycin should not be reconstituted with inorganic salt solution. Use only Water for Injection.
Subsequent dilution into infusion fluids should be made prior to administration. Recommended fluids are Sodium Chloride Injection B.P. 0.9% Dextrose 5% Injection B.P. The stability of solutions of Erythromycin Lactobionate is adversely affected below pH 5.5. 5ml of sterile 8.4% sodium bicarbonate solution will neutralize 1 litre of Glucose Injection B.P. 5% and should be added to the bag prior to addition of Erythromycin Lactobionate.
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