Estradiol - subcutaneous

Patient Medicine Information
Why do I need this medicine?
Estradiol is used as a hormone replacement therapy (HRT) in menopausal women. It is used to treat symptoms associated with menopause such as hot flushes, sleep disturbances, mood swings and vaginal dryness or irritation.

This medicine may be used to treat other conditions as decided by your doctor.
How do I use this medicine?
Estradiol is to be given subcutaneously (under the skin). Your doctor or nurse will administer this medicine for you. Try to be on time during your scheduled appointments.

You may need to use Estradiol for some time before the full benefits can be felt. Continue with the treatment even when you feel better. Do not stop treatment unless instructed by the doctor.
What should I do if I have forgotten to use this medicine?
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Estradiol.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • blood clot disorder
  • liver disease
  • recent heart attack
  • recent stroke
  • known, suspected or history of cancer of the breast, lining of the womb or ovaries
  • unexplained or unusual vaginal bleeding
as this medicine may not be suitable for you.

Do not use Estradiol if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with this medicine, alert your doctor immediately. Estradiol may cause harm to your unborn child. You must use proven birth control methods while using this medicine.
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • epilepsy (fits or seizures)
  • asthma
  • migraine
  • kidney disease
  • heart disease or risk factors for heart disease e.g. high blood pressure, diabetes, high cholesterol
  • gallbladder disease
  • thyroid problems e.g. low activity of the thyroid gland
  • low calcium level in the blood
  • systemic lupus erythematosus (autoimmune disease that causes inflammation)
  • porphyria (inherited disorder that may cause skin or nerve problems)
Let your doctor know if you are breastfeeding.

If you are going for any laboratory tests, inform your doctor that you are being treated with Estradiol as it can interfere with certain tests.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly. Your doctor may need to do routine physical examination while you are being treated with this medicine.
What side effects could I experience?
Estradiol may cause any of the following side effects: headache, nausea, stomach pain, stomach wind, bloating, vaginal discharge or irritation, breast tenderness, nipple pain, skin rash, itching, pain in the joint, muscle, limb or back and injection site reactions.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • difficulty breathing or chest discomfort
  • severe headache or migraine
  • visual disturbances
  • breast lumps, dimples in the skin around the breast or changes in the nipple
  • abnormal vaginal bleeding
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for TB e.g. rifampicin
  • medicines for epilepsy (fits or seizures) e.g. phenobarbital, phenytoin, carbamazepine
  • medicines for HIV e.g. ritonavir
This list does not include all medicines that may interact with Estradiol.

Always notify your doctor or pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on estradiol - subcutaneous and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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