Pharmacology: Mechanism of Action: Fish Oils provide the essential Omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
EPA + DHA supplementation ranging from 0.5 to 1.8g/d significantly reduces subsequent cardiac and all-cause mortality. EPA + DHA supplementation of 2 to 4g/d as component of the medical management of hypertriglyceridemia.
Potential mechanisms by which natural Omega-3 may reduce risk for CVD includes: decrease very low density lipoprotein (VLDL) and triglycerides, reduce susceptibility of the heart to ventricular arrhythmia, antithrombogenic, retard growth of atherosclerotic plaque, promote nitric-induced endothelial relaxation and mildly hypotensive.
Moderate to severe vitamin D deficiency is a risk factor for developing cardiovascular diseases. Several mechanisms may explain the link between vitamin D deficiency and CVD; participate in the regulation of renin-angiotensin, inhibition of vascular smooth-muscle proliferation, suppression of vascular calcification, regulation of inflammatory cytokines.