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Exforge

Exforge

amlodipine + valsartan

Manufacturer:

Novartis

Distributor:

DKSH
Concise Prescribing Info
Contents
Per 5/80 mg tab Amlodipine besylate 5 mg, valsartan 80 mg. Per 5/160 mg tab Amlodipine besylate 5 mg, valsartan 160 mg. Per 10/160 mg tab Amlodipine besylate 10 mg, valsartan 160 mg
Indications/Uses
Essential HTN in patients whose BP is inadequately controlled by monotherapy.
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Dosage/Direction for Use
Adult 1 tab daily.
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Overdosage
View Exforge overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Concomitant use w/ aliskiren in diabetic type 2 patients. Severe hepatic impairment, biliary cirrhosis & cholestasis. Pregnancy.
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Special Precautions
Discontinue immediately & not to be re-administered in patients w/ history of or angioedema. Not recommended as initial therapy in patients w/ intravascular vol depletion. Risk of hypotension in Na- &/or vol-depleted patients. Unilateral or bilateral renal artery stenosis, stenosis to solitary kidney or after recent kidney transplantation. Heart failure, severe chronic heart failure or other conditions w/ renin-angiotensin-aldosterone system stimulation; acute MI; severe obstructive CAD; aortic or mitral stenosis or obstructive hypertrophic cardiomyopathy. Avoid concomitant use w/ aliskiren in patients w/ severe renal impairment. Avoid co-administration w/ ACE inhibitors. Severe renal impairment (CrCl <10 mL/min) & dialysis. Not recommended in childn <18 yr.
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Adverse Reactions
Nasopharyngitis, flu, headache, peripheral, pitting & facial oedema, hot flush, fatigue, flushing, asthenia, dizziness, somnolence, postural dizziness, paraesthesia, vertigo, tachycardia, palpitations, orthostatic hypotension, cough, pharyngolaryngeal & abdominal pain, diarrhea, nausea, constipation, dry mouth, rash, erythema, joint swelling, back pain, arthralgia.
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Drug Interactions
Amlodipine: Increased exposure of simvastatin. Increased plasma conc w/ CYP3A4 inhibitors. Valsartan: Concomitant use w/ K supplements, K-sparing diuretics, K-containing salt substitutes or other drugs that increase K levels. Attenuated antihypertensive effects w/ NSAIDs. Increased valsartan systemic exposure w/ uptake transporter inhibitors (rifampin, ciclosporin) or efflux transporter (ritonavir).
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Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Exforge detailed prescribing information
Description
View Exforge description for details of the chemical structure and excipients (inactive components).
Action
View Exforge mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Angiotensin II Antagonists / Calcium Antagonists
ATC Classification
C09DB01 - valsartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Exforge 10/160 mg FC tab
Packing/Price
14's;28's;7's
Form
Exforge 5/160 mg FC tab
Packing/Price
14's;28's;7's
Form
Exforge 5/80 mg FC tab
Packing/Price
14's;28's;7's
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