10 mg once daily, used alone or w/ statin. When co-administered w/ statin, consult dosage instructions for that particular statin. The stepwise increase of statin dose in combination treatment results in relatively small additional decrease of LDL-C, but increases risk of dose-related adverse events of the statin. This has to be considered for the risk-benefit-assessment when statin dose is considered. Co-administration w/ bile acid sequestrants: Dosing of Ezetrol should occur either ≥2 hr before or ≥4 hr after administration of bile acid sequestrants.
When co-administered w/ statin, perform liver function tests at baseline & according to the recommendations of the statin. Not recommended for moderate (Child-Pugh scores 7-9) or severe (Child-Pugh score >9) liver dysfunction. Co-administration w/ fibrates not recommended. Caution when initiating Ezetrol in the setting of cyclosporine. Monitor cyclosporine conc. Pregnancy & lactation. Not recommended for childn <10 yr.