10 mg once daily, used alone or w/ statin. When co-administered w/ statin, consult dosage instructions for that particular statin. The stepwise increase of statin dose in combination treatment results in relatively small additional decrease of LDL-C, but increases risk of dose-related adverse events of the statin. This has to be considered for the risk-benefit-assessment when statin dose is considered. Co-administration w/ bile acid sequestrants: Dosing of Ezetrol should occur either ≥2 hr before or ≥4 hr after administration of bile acid sequestrants.
View Ezetrol overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Combination w/ HMG-CoA reductase inhibitor in patients w/ active liver disease or unexplained persistent elevations in serum transaminases.
When co-administered w/ statin, perform liver function tests at baseline & according to the recommendations of the statin. Not recommended for moderate (Child-Pugh scores 7-9) or severe (Child-Pugh score >9) liver dysfunction. Co-administration w/ fibrates not recommended. Caution when initiating Ezetrol in the setting of cyclosporine. Monitor cyclosporine conc. Pregnancy & lactation. Not recommended for childn <10 yr.
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