LG Chem


Pahang Pharmacy
Concise Prescribing Info
Gemifloxacin mesylate
Mild to moderate community-acquired pneumonia.
Dosage/Direction for Use
Pneumonia due to S pneumoniae, H influenzae, M pneumoniae or C pneumoniae infection 1 tab once daily for 5 days. Pneumonia due to MDRSP, K pneumoniae or M catarrhalis infection 1 tab once daily for 7 days. Severe renal impairment, haemodialysis & continuous ambulatory peritoneal dialysis (CAPD) patient 160 mg once daily.
May be taken with or without food.
Hypersensitivity to gemifloxacin or other quinolones. History of gemifloxacin or other quinolone-associated tendonitis & tendon rupture. Pregnancy & lactation. Childn or adolescents <18 yr.
Special Precautions
Discontinue use if hypersensitivity, tendon pain, swelling, inflammation or rupture occurs. Previous tendon disorder eg, RA. Increased risk of peripheral neuropathy. Clostridium difficile-associated diarrhea. Epilepsy, patients predisposed to convulsions. Known history of myasthenia gravis & QTc interval prolongation. Uncorrected electrolyte disorders (hypokalemia or hypomagnesemia). Patients w/ ongoing proarrhythmic conditions eg, significant bradycardia or acute myocardial ischemia; kidney, heart or lung transplants. Avoid strenuous physical activity & excessive sun or UV light exposure. Concomitant use w/ class IA or III antiarrhythmic agents & corticosteroid drugs. May affect ability to drive & use machines. Renal & hepatic impairment. Not to be used during pregnancy & lactation. Childn & adolescents <18 yr. Elderly >60 yr.
Adverse Reactions
Shock; increased ICP & CNS stimulation; abdominal pain, vomiting, constipation, dry mouth, dyspepsia, flatulence, gastritis, hyperglycemia; transient elevation of liver enzymes; rash, hives, itching; dermatitis, fungal infection, genital pruritus, vaginitis; arthralgia, tendonitis, increased creatine phosphokinase; decreased & increased platelets, decreased leucopenia, fatigue, taste perversion. SJS & Lyell's syndrome. Exacerbation of myasthenia gravis.
Drug Interactions
Reduced absorption w/ Al- &/or Mg-containing antacids, ferrous sulphate, Ca prep, Zn- or Fe-containing multivit prep. Increased INR or prothrombin time &/or clinical bleeding episodes w/ warfarin & its derivatives. Didanosine, sucralfate, Ca carbonate.
MIMS Class
ATC Classification
J01MA15 - gemifloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Factive FC tab 320 mg
1 × 5's;1 × 7's
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