Fenoterol


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Acute bronchospasm 2.5-5 mg tid. Max: 15 mg/day. Inhalation Acute asthma As inhaler: 1 inhalation, if symptoms are not adequately controlled after 5 min, a 2nd dose may be given. As soln: 0.5 mL; may require higher doses between 1-1.25 mL in severe cases. Prophylaxis of exercise-induced asthma; Reversible airways obstruction As inhaler: 1-2 inhalations. Max: 8 inhalations/day. As soln: 0.5 mL up to 4 times/day.
Dosage Details
Inhalation/Respiratory
Prophylaxis of exercise-induced asthma, Reversible airways obstruction
Adult: As metered-dose inhaler (100 mcg/dose): 1-2 inhalations as needed. Max: 8 inhalations daily. As soln (50 mcg/drop): 0.5 mL (10 drops or 500 mcg) up to 4 times daily.

Inhalation/Respiratory
Acute asthma
Adult: As metered-dose inhaler (100 mcg/dose): 1 inhalation as needed, if symptoms are not adequately controlled after 5 min, a 2nd dose may be given. As soln (50 mcg/drop): 0.5 mL (10 drops or 500 mcg), may require higher doses between 1-1.25 mL (20-25 drops or 1,000-1,250 mcg) in severe cases.
Child: 6-12 yr 22-36 kg/body wt: As soln (50 mcg/drop): 0.25-0.5 mL (5-10 drops or 250-500 mcg). May require higher doses up to 1 mL (20 drops or 1,000 mcg) in severe cases.

Oral
Acute bronchospasm
Adult: 2.5-5 mg tid. Max: 15 mg daily.
Contraindications
Hypertrophic obstructive cardiomyopathy, tachyarrhythmia.
Special Precautions
Patient w/ severe asthma, underlying severe heart disease (e.g. ischaemic heart disease, severe organic heart disease, arrhythmia, severe heart failure), insufficiently controlled DM, recent MI, hyperthyroidism, phaeochromocytoma, and severe vascular disorder. Pregnancy and lactation.
Adverse Reactions
Hypokalaemia, hypersensitivity, nervousness, agitation, headache, dizziness, tremor, palpitations, myocardial ischaemia, tachycardia, arrhythmia, nausea, vomiting, hyperhidrosis, skin reactions (e.g. urticaria, rash, pruritus), myalgia, muscular weakness, muscle spasm, paradoxical bronchospasm, cough, throat irritation, increased systolic and decreased diastolic BP.
MonitoringParameters
Monitor serum K levels.
Overdosage
Symptoms: Palpitation, tachycardia, tremor, HTN, hypotension, widening of pulse pressure, anginal pain, arrhythmias, flushing, metabolic acidosis. Management: Admin of tranquilisers, sedatives in severe cases; β-receptor blockers preferably β1-selective. Intensive therapy may be required.
Drug Interactions
Increased effect w/ β-adrenergics, anticholinergics, MAOIs, TCAs and xanthine derivatives (e.g. theophylline). Serious reduction in bronchodilation w/ β-blockers. May enhance susceptibility to CV effects w/ halothane, enflurane, and trichloroethylene.
Action
Description: Fenoterol is a direct-acting sympathomimetic agent w/ predominant β-adrenoceptor stimulant activity largely selective for β2-receptors.
Onset: W/in a few min (inhalation).
Duration: Approx 3-5 hr (inhalation).
Pharmacokinetics:
Absorption: Incompletely absorbed from the GI tract.
Distribution: Enters breast milk.
Metabolism: Undergoes extensive first-pass metabolism via sulfate conjugation
Excretion: Via urine and bile (mainly as inactive sulfate conjugate).
Chemical Structure

Click on icon to see table/diagram/image
Storage
Store below 30°C.
ATC Classification
R03CC04 - fenoterol ; Belongs to the class of adrenergics for systemic use, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.
R03AC04 - fenoterol ; Belongs to the class of adrenergic inhalants, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.
Disclaimer: This information is independently developed by MIMS based on Fenoterol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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