Finil 16

Finil 16

candesartan

Manufacturer:

Unison

Distributor:

Medispec
Concise Prescribing Info
Contents
Candesartan cilexetil
Indications/Uses
HTN, heart failure & impaired left ventricle systolic function (ejection fraction ≤40%) as add-on therapy to ACE inhibitors or when ACE inhibitors are not tolerated.
Dosage/Direction for Use
HTN Initially 8 mg once daily, may be increased to 16 mg once daily. May be further increased to max: 32 mg once daily if BP is not sufficiently controlled after 4 wk of treatment. Heart failure Initially 4 mg once daily. Up-titration to target dose: 32 mg once daily or highest tolerated dose by doubling dose at 2-wk intervals at least.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Concomitant use w/ aliskiren-containing products in patients w/ DM or renal impairment (GFR <60 mL/min/1.73 m2). Severe hepatic impairment &/or cholestasis. 2nd & 3rd trimesters of pregnancy. Childn <1 yr.
Special Precautions
Hypersensitivity to bisulphites. Not recommended in dual blockade of renin-angiotensin-aldosterone system & primary aldosteronism. Not to be used concomitantly w/ ACE inhibitors in patients w/ diabetic nephropathy, heart failure. Bilateral renal artery stenosis or artery stenosis to solitary kidney; hypotension; aortic & mitral stenosis (obstructive hypertrophic cardiomyopathy); ischaemic cardiopathy or cerebrovascular disease. Anaesth & surgery. Periodically monitor serum K & creatinine levels; electrolytes. Monitor BP in patients on hemodialysis. Not recommended in combination w/ ACE inhibitors, K-sparing diuretic eg, spironolactone; mineralocorticoid-receptor antagonist; medicinal products w/ BP-lowering effects. Not to be taken by patients w/ galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Very severe or end-stage renal impairment (CrCl <15 mL/min); recent kidney transplantation. Not recommended during 1st trimester of pregnancy & lactation. Childn w/ GFR <30 mL/min/1.73 m2; childn & adolescents <18 yr. Elderly ≥75 yr.
Adverse Reactions
Resp infection; dizziness/vertigo, headache. Hyperkalemia; hypotension; renal impairment.
Drug Interactions
Increased K levels w/ K-sparing diuretics, K supplements or K-containing salt substitutes, heparin. Reversible increased serum lithium conc & toxicity. Attenuated antihypertensive effects w/ NSAIDs eg, selective COX-2 inhibitors, acetylsalicylic acid >3 g daily, non-selective NSAIDs. Increased risk of worsened renal function w/ ACE inhibitors, NSAIDs.
ATC Classification
C09CA06 - candesartan ; Belongs to the class of angiotensin II receptor blockers (ARBs). Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Finil 16 tab 16 mg
Packing/Price
10 × 10's
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