Hypersensitivity to bisulphites. Not recommended in dual blockade of renin-angiotensin-aldosterone system & primary aldosteronism. Not to be used concomitantly w/ ACE inhibitors in patients w/ diabetic nephropathy, heart failure. Bilateral renal artery stenosis or artery stenosis to solitary kidney; hypotension; aortic & mitral stenosis (obstructive hypertrophic cardiomyopathy); ischaemic cardiopathy or cerebrovascular disease. Anaesth & surgery. Periodically monitor serum K & creatinine levels; electrolytes. Monitor BP in patients on hemodialysis. Not recommended in combination w/ ACE inhibitors, K-sparing diuretic eg, spironolactone; mineralocorticoid-receptor antagonist; medicinal products w/ BP-lowering effects. Not to be taken by patients w/ galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Very severe or end-stage renal impairment (CrCl <15 mL/min); recent kidney transplantation. Not recommended during 1st trimester of pregnancy & lactation. Childn w/ GFR <30 mL/min/1.73 m2
; childn & adolescents <18 yr. Elderly ≥75 yr.