Flamex

Flamex

Manufacturer:

KCK Pharma

Distributor:

Unimed
Full Prescribing Info
Contents
Sodium alginate, dried Aluminum hydroxide, Calcium carbonate.
Description
Each 5 ml contains: Sodium Alginate 250 mg, Dried Aluminium Hydroxide 100 mg, Calcium Carbonate 75 mg.
Excipients/Inactive Ingredients: Preservatives: Sodium Methyl Paraben 0.14% w/v, Sodium Propyl Paraben 0.08% w/v, Cetylpyridinium Chloride 0.1% w/v.
Action
Pharmacology: Pharmacodynamics: Sodium Alginate is used with an antacid or a H2 - receptor antagonist, in the management of gastro-oesophageal reflux. The alginate reacts with gastric acid to form a viscous gel (often termed a raft) which floats on top of the gastric contents. This raft then acts as a mechanical barrier to reduce reflux.
Aluminium Hydroxide is an antacid. It is given orally in doses up to 1g, between meals and at bedtime.
Calcium carbonate is used as an antacid, usually in oral doses of up to 1.5g. Calcium carbonate binds phosphate in the gastrointestinal tract to form insoluble complexes and reduce phosphate absorption.
Pharmacokinetics: Aluminium hydroxide slowly reacts with the hydrochloric acid in the stomach to form soluble aluminium chloride, some of which is absorbed.
The aluminium compounds remaining in the gastrointestinal tract, which account for most of a dose, form insoluble, poorly absorbed aluminium salts in the intestines including hydroxides, carbonates, phosphates and fatty acid derivatives, which are excreted in the faeces.
Calcium carbonate is converted to calcium chloride by gastric acid. Some of the calcium is absorbed from the intestines and the unabsorbed portion is excreted in the faeces.
Indications/Uses
FlameX Suspension is indicated in the relief of symptoms of gastroesophageal reflux such as acid regurgitation, heartburn and indigestion.
Dosage/Direction for Use
Adults and children over 12 years: 10-20 ml after meals and at bedtime, up to four times a day.
Children under 12 years: Should be given only on medical advice.
Route of Administration: Oral.
Overdosage
High doses or prolonged use may lead to gastric hyper secretion and acid rebound. Calcium carbonate can cause hypercalcaemia, particularly in patients with renal impairment or after high doses.
In the event of over dose, Symptomatic treatment should be given.
Contraindications
Hypersensitivity to any of the ingredients.
Special Precautions
If symptoms do not improve after seven days, the clinical situation should be reviewed.
Treatment of children younger than 12 years of age is not generally recommended, except on medical advice.
Use In Pregnancy & Lactation
FlameX suspension may be used during pregnancy, but under supervision of a doctor.
Adverse Reactions
Aluminium hydroxide is astringent and may cause constipation; large doses can cause intestinal obstruction.
Excessive doses, or even normal doses in patients with low-phosphate diets, may lead to phosphate depletion accompanied by increased bone resorption and hypercalciuria with the risk of osteomalacia.
Calcium carbonate may occasionally cause constipation.
Drug Interactions
Aluminium compounds used as antacids interact with many other drugs, both by alterations in gastric pH and emptying, and by direct adsorption and formation of complexes that are not absorbed. Interactions can be minimized by giving the aluminium compound and any other medication 2 to 3 hours apart.
Calcium salts interact with many other drugs, both by alterations in gastric pH and emptying, and by formation of complexes that are not absorbed. Interactions can be minimized by giving calcium carbonate and any other medication 2 to 3 hours apart.
Storage
Store below 30°C.
ATC Classification
A02AX - Antacids, other combinations ; Used in the treatment of acid-related disorders.
Presentation/Packing
Oral susp (pink colour with orange flavour) 100 mL, 200 mL.
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