Replacement therapy in primary immunodeficiency syndromes
Starting dose: 0.4-0.8 g/kg followed by 0.2-0.8 g/kg 2-4 wkly to achieve IgG trough level of 4-6 g/L. Replacement therapy in myeloma or chronic lymphatic leukaemia w/ severe secondary hypogammaglobulinaemia & recurrent infections; replacement therapy in childn w/ AIDS & recurrent infections
0.2-0.4 g/kg 3-4 wk. ITP
0.8-1 g/kg on day 1, may be repeated once w/in 3 days, or 0.4 g/kg daily for 2-5 days. Guillain-Barre syndrome
0.4 g/kg daily for 3-7 days. Kawasaki disease
1.6-2 g/kg in divided doses over 2-5 days or 2 g/kg as a single-dose in combination w/ acetylsalicylic acid. Allogeneic bone marrow transplantation
0.5 g/kg wkly starting 7 days before & up to 3 mth after transplantation for the treatment of infections & prophylaxis of graft versus host disease, & 0.5 g/kg mthly until Ab levels return to normal in persistent lack of Ab production.