Fluanxol (Low Dosage)

Fluanxol (Low Dosage)

flupentixol

Manufacturer:

Lundbeck

Distributor:

Zuellig Pharma
Full Prescribing Info
Contents
Flupentixol diHCl.
Action
Flupentixol dihydrochloride in daily doses of up to 3 mg possesses antidepressant, anxiolytic and activating properties which have been shown in many controlled, clinical trials. Its effect can be seen promptly ie, during the 1st week of treatment and also ceases soon after discontinuation.
Pharmacokinetics: The bioavailability after oral administration of flupentixol is about 40%. Maximum serum concentration is reached in 3-6 hrs. Flupentixol in small amounts crosses the placental barrier and is excreted in small amounts into the breast milk. The metabolites are devoid of psychopharmacological activity. The excretion proceeds mainly with feces but also to some degree with the urine. The biological half-life is about 35 hrs.
Indications/Uses
Depression involving anxiety, asthenia and lack of initiative. Chronic neuroses with anxiety, depression and inactivity. Psychosomatic disorders with asthenic reactions. Acute and situational anxiety and tension states in which a sedative/hypnotic effect is not required and especially when the patient is considered in danger of abusing minor tranquilizers.
Dosage/Direction for Use
Initially, 0.5 mg twice daily. Later the dose may be adjusted within the range of 0.5-3 mg daily.
Patients often respond to Fluanxol (Low Dosage) within 2 or 3 days. If no effect has been observed within 1 week of maximum dosage (3 mg daily) the drug should be withdrawn.
Overdosage
Treatment is symptomatic and supportive. Gastric lavage should be carried out immediately and activated charcoal may be administered. Measures aimed at supporting the respiratory and cardiovascular systems should be instituted; epinephrine must not be used for such patients.
Contraindications
Extremely excitable and overactive patients. Acute barbiturate, alcohol and opiate poisoning. Like other psychotropics, Fluanxol (Low Dosage) should preferably not be given during pregnancy. Comatose states, bone marrow depression.
Special Precautions
Fluanxol (Low Dosage) should be used with caution in patients with severe hepatic or renal disease. If previously the patient has been treated with tranquilizers with a sedative effect, these should be withdrawn gradually.
Use In Pregnancy & Lactation
Like other psychotropics, Fluanxol (Low Dosage) should preferably not be given during pregnancy.
Side Effects
Occasional: Restlessness and/or insomnia. Rare: Extrapyramidal symptoms, if recommended dosage is exceeded.
Drug Interactions
Fluanxol (Low Dosage) may enhance the response to alcohol and the effects of barbiturates and other CNS depressants. It should not be given concomitantly with guanethidine or similarly acting compounds, since neuroleptics may block the antihypertensive effect of these compounds. Fluanxol (Low Dosage) may lower the effect of adrenergic drugs and concomitant use of metoclopramide and piperazine increases the risk of extrapyramidal symptoms.
MIMS Class
ATC Classification
N05AF01 - flupentixol ; Belongs to the class of thioxanthene derivatives antipsychotics.
Presentation/Packing
Tab 0.5 mg (coated) x 100's.
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