Adults: Cryptococcal Meningitis and Cryptococcal Infections at Other Sites: 400 mg on the first day followed by 200-400 mg daily usually for at least 6-8 weeks.
Prevention of Relapse of Cryptococcal Meningitis in Patients with AIDS: Fluconazole may be administered indefinitely at a daily dose of at least 200 mg after the patient receives a full course of primary therapy.
Candidaemia, Disseminated Candidiasis and Other Invasive Candidal Infections: 400 mg on the first day followed by 200 mg daily. The dose may be increased to 400 mg daily depending on the clinical response. Duration of treatment depends on the clinical response.
Oropharyngeal Candidiasis: 50-100 mg once daily, given for 7 - 14 days. If necessary, treatment should not be normally exceed 14 days except in severely immunocompromised patients.
Atrophic Oral Candidiasis Associated with Dentures: 50 mg once daily for 14 days administered concurrently with local antiseptic measures to the denture.
Other Candidal Infections of The Mucosa, (except vaginal candidiasis), eg oesophagitis, noninvasive bronchopulmonary infections, candiduria, mucocutaneous candidiasis, etc.: 50 mg daily for 14-30 days. The dose may be increased to 100 mg dose in unusually difficult cases of mucosal candidal infections.
Vaginal Candidiasis: 150 mg should be administered as a single oral dose. To reduce the incidence of recurrent vaginal candidiasis, a 150 mg once monthly dose may be used, the duration of therapy should be individualized, but ranges from 4-12 months. Some patients may require a more frequent dosing.
For the prevention of candidiasis, the recommended dosage is 50 - 400 mg once daily. It is based on the patient's risk of developing fungal infection.
For patients at high risk of systemic infection, eg patients who are anticipated to have profound or prolonged neutropenia, the recommended dosage is 400 mg once daily. Fluconazole administration should start several days before the anticipated onset of neutropenia, and continuing for 7 days after the neutrophil count rises above 1000 cells/mm3.
The recommended dosage is 150 mg once weekly or 50 mg once daily for dermal infections including corporis, tinea pedis, cruris and candida infections. Duration of treatment is usually 2-4 weeks but tinea pedis may require treatment for up to 6 weeks.
Tinea versicolor: Recommended dose is 300mg once weekly for 2 weeks; a 3rd weekly dose of 300mg may be needed in some patients, whereas, in some patients, a single dose of 300-400 mg may be sufficient. An alternate dosing regimen is 50 mg once daily for 2-4 weeks.
Elderly: If there is no evidence of renal impairment, normal recommended doses should be used. For patients with renal impairment (creatinine clearance < 40 ml/min) the dosage schedule should be adjusted as follows: Patient with Renal Impairment: Fluconazole is cleared primarily by renal excretion as unchanged drug. There is no need to adjust single dose therapy. In multiple-dose therapy, normal doses should be given on days 1 and 2 of treatment, and thereafter the dosage intervals of daily dose should be modified in accordance with creatinine clearance as follows: (See table.)
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