Fluconazole is generally well tolerated. The undesirable effects associated with fluconazole are: Nervous System Disorders: Headache, dizziness, seizures, taste perversion.
Skin and Subcutaneous Tissue Disorders: Rash, alopecia, exfoliative skin disorders including Stevens-Johnson syndrome and toxic epidermal necrosis.
Gastrointestinal Disorders: Abdominal pain, diarrhea, flatulence, nausea, dyspepsia, vomiting. In some patients, particularly those with serious underlying disease such as AIDS and cancer, changes in renal and haematological function test results and hepatic abnormalities have been observed during treatment with fluconazole and comparative agents, but the clinical significance and relationship to treatment is uncertain.
Hepatobiliary Disorders: Hepatic toxicity including rare cases of fatalities, elevated alkaline phosphatase, elevated bilirubin, elevated SGOT, elevated SGPT, hepatic failure, hepatitis, hepatocellular necrosis, jaundice.
Blood and Lymphatic System Disorders: Leukopenia including neutropenia and agranulocytosis, throcytopenia.
Immune system Disorders: allergic reaction: anaphylaxis (including angioedema, face oedema, pruritus), urticaria.
Metabolism and Nutrition Disorders: Hypercholesterolaemia, hypertriglyceridaemia, hypokalaemia.
Cardiac Disorders: QT prolongation, torsade de pointes.