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Use in Pregnancy: There are no adequate and well controlled studies in pregnant women. Multiple congenital abnormalities have been reported in infants whose mothers were being treated for 3 or more months with high dose (400-800 mg/day) fluconazole therapy for coccidioidomycosis (an unindicated use). The relationship between fluconazole and these events is unclear. However, use of fluconazole in pregnancy is not recommended except in patients with severe or potentially life-threatening fungal infections in whom fluconazole may be used if the potential benefit justifies the possible risk to the fetus.
Use in Lactation: Fluconazole is secreted in human breast milk at concentrations similar to plasma. Thus, its use in nursing mothers should be avoided.
