Fluorescein


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Assessment of exocrine pancreatic function As dilaurate: 348.5 mg as a single dose. Collect urine for the next 10 hr. A control dose of 188.14 mg of fluorescein Na is given the next day under the same conditions. IV Angioscopy of the retinal and iris vasculature 500 mg (as 500 mg/5 mL solution) as single dose via rapid inj into the antecubital vein at a rate of 1 mL per second. Ophth Aid in fitting hard contact lenses; Detection of corneal lesions and foreign bodies; Diagnostic ophth procedures Instill dropwise onto the affected eye(s). As a sterile strip impregnated with 0.6 or 1 mg fluorescein sodium: Apply tip to conjunctiva or formix until adequately stained.
Dosage Details
Intravenous
Angioscopy of the retinal and iris vasculature
Adult: 500 mg (as 500 mg/5 mL solution) as a single dose via rapid inj into the antecubital vein at a rate of 1 mL per second.  For highly sensitive imaging system, reduce dose to 200 mg.
Child: 7.7 mg/kg as a single dose into antecubital vein. Max: 500 mg.

Ophthalmic
Aid in the fitting of hard contact lenses, Detection of corneal lesions and foreign bodies, Diagnostic ophthalmic procedures
Adult: As 1% or 2% solution: Instill dropwise onto the affected eye(s). As a sterile strip impregnated with 0.6 or 1 mg fluorescein sodium: Apply tip to conjunctiva or formix until adequately stained.

Oral
Assessment of exocrine pancreatic function
Adult: 348.5 mg fluorescein dilaurate (equivalent to 0.5 mmol of fluorescein), given with meal. Collect urine for the next 10 hour. A control dose of 188.14 mg fluorescein Na (equivalent to 0.5 mmol of fluorescein) is given the following day under the same conditions.
Contraindications
Acute necrotising pancreatitis (oral fluorescein dilaurate).
Adverse Reactions
Nausea and vomiting (IV); extravasation is painful; hypersensitivity reactions; transient yellow coloration of skin and urine; staining of the skin, clothing and soft contact lenses.
Potentially Fatal: Cardiac arrest and fatalities.
IV/Ophth/Parenteral: C
Action
Description: Fluorescein, a precursor of the eosins, temporarily stains any cell it enters therefore marking any damaged areas.
Disclaimer: This information is independently developed by MIMS based on Fluorescein from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
  • Fluorets
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