Fluorescite

Fluorescite Dosage/Direction for Use

fluorescein

Manufacturer:

Alcon

Distributor:

DKSH
Full Prescribing Info
Dosage/Direction for Use
Use in adults, including the elderly: Inject 5 mL of Fluorescein 10% solution for injection rapidly into the antecubital vein after taking precautions to avoid extravasation. In cases when highly sensitive imaging systems, e.g., scanning laser ophthalmoscope are used, the dose of this product should be reduced to 2 mL of Fluorescein 10% solution for injection.
Use in paediatric patients: For children, the dose should be calculated on the basis of 35 mg for each 10 pounds of body weight (7.7 mg/kg body weight).
Use in patients with renal insufficiency (glomerular filtration rate below 20 mL/min): Limited experience in renally impaired patients (glomerular filtration rate below 20 mL/min) suggests that, in general, no dose adjustment is required although a longer excretion rate in patients with renal impairment is possible.
Dialyzed patients: Reduce dose to 2.5 mL (half a vial).
Administration: Fluorescein 10% solution for injection should be used exclusively by qualified physicians with technical expertise in performing and interpreting fluorescence angiography.
This product should only be administered intravenously.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Do not mix or dilute with other solutions or drugs. Flush intravenous cannulas before and after drugs are injected to avoid physical incompatibility reactions.
Inject the dose rapidly (1 mL per second is normally recommended) into the antecubital vein, after taking precautions to avoid extravasation. A syringe, filled with Fluorescein 10% solution may be attached to transparent tubing and a 23 gauge butterfly needle for injection. Insert the needle and draw the patient's blood to the hub of the syringe so that a small air bubble separates the patient's blood in the tubing from the fluorescein. With the room lights on, slowly inject the blood back into the vein while watching the skin over the needle tip. If the needle has extravasated, the patient's blood will be seen to bulge the skin and the injection should be stopped before any fluorescein is injected. When assured that extravasation has not occurred, the room light may be turned off and the fluorescein injection completed. Luminescence usually appears in the retina and choroidal vessels in 7 to 14 seconds and can be observed by standard viewing equipment.
Flush intravenous cannulas with sterile sodium chloride solution (0.9%) before and after medicinal products are injected to avoid physical incompatibility reactions. The injection should be administered rapidly (1 mL per second is normally recommended) into the antecubital vein, after taking precautions to avoid extravasation using a 23 gauge butterfly needle for injection. Luminescence usually appears in the retina and choroidal vessels in 7 to 14 seconds.
Any unused product or waste material should be disposed of in accordance with local requirements.
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