Zuellig Pharma
Concise Prescribing Info
Ceftazidime pentahydrate
Severe infections & resp tract, ENT, urinary tract & GIT, biliary & abdominal infections, skin & soft tissue infections, bone & joint infections & infections associated w/ haemo- & peritoneal dialysis w/ continuous ambulatory peritoneal dialysis (CAPD).
Dosage/Direction for Use
Adult 1-6 g daily IV or IM inj in 2 or 3 divided doses. Urinary tract & less severe infections 500 mg or 1 g every 12 hr. Most infections 1 g every 8 hr or 2 g every 12 hr. Very severe infections in immunocompromised patient including those w/ neutropenia 2 g every 8 or 12 hr or 3 g every 12 hr. Fibrocystic adult w/ pseudomonal lung infections 100-150 mg/kg daily in 3 divided doses. Infant & childn >2 mth 30-100 mg/kg daily in 2 or 3 divided doses. Immunocompromised or fibrocystic childn or childn w/ meningitis Up to 150 mg/kg daily in 3 divided doses. Max: 6 g daily. Neonate 0-2 mth 25-60 mg/kg daily in 2 divided doses. Elderly Max: 3 g daily. Renal impairment CrCl 31-50 mL/min 1 g every 12 hr, 16-30 mL/min 1 g every 24 hr, 6-15 mL/min 0.5 g every 24 hr, <5 mL/min 0.5 g every 48 hr. Renal failure patient on continuous arteriovenous haemodialysis or high-flux haemofiltration 1 g daily as single dose or in divided doses.
Hypersensitivity to cephalosporins.
Special Precautions
Hypersensitivity to cephalosporins, penicillins or other β-lactams. Overgrowth of nonsusceptible organisms. Pseudomembranous colitis. Prolonged use. Concurrent use w/ high-doses of aminoglycosides or potent diuretics eg, furosemide. Renal impairment. Pregnancy & lactation.
Adverse Reactions
Eosinophilia, thrombocytosis; phlebitis or thrombophlebitis (IV); diarrhoea; transient hepatic enzyme elevations, ALT, AST, LDH, GGT & alkaline phosphatase; maculopapular or urticarial rash; pain &/or inflammation (IM); +ve Coombs' test.
Drug Interactions
Affected renal function w/ nephrotoxic drugs. Lowered oestrogen reabsorption & reduced efficacy of combined OC. Possible antagonism w/ chloramphenicol.
MIMS Class
ATC Classification
J01DD02 - ceftazidime ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Fortum IV/IM powd for inj 1 g
Fortum IV powd for inj 2 g
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