Hypersensitivity has rarely been encountered. As with other topical corticosteroids, prolonged and intensive treatment may cause local atrophic changes of the skin, such as striae, thinning and dilatation of the superficial blood vessels, particularly when occlusive dressing is used or when skin folds are involved. Systemic absorption, sufficient to produce hypercorticism/adrenal suppression, can occur with prolonged or extensive use, especially when used under occlusion/napkin.
Infants and children are particularly at risk.
Caution should be exercised if a topical steroid is used near the eye. Glaucoma might be the result if the preparation enters the eye.