Reversible hypothalamic-pituitary-adrenal axis suppression. Not to be used for >7 days in absence of any clinical improvement. Increased risk of developing antibiotic resistance on extended or recurrent use. Increased susceptibility to infection, aggravation of existing infection, activation of latent infection. May mask symptoms of infection. May cause local skin reactions, mucous membrane or eye irritation due to butylhydroxyanisole, cetyl alcohol & K sorbate. Avoid long-term continuous therapy. Avoid contact w/ eyes. Not to be used extensively, in large amounts or for prolonged use during pregnancy. Avoid topical breast application during breastfeeding. Childn.