Fusidic acid


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Cutaneous staphylococcal infections 250 mg twice daily. Staphylococcal infections 500 mg 8 hrly, may double in severe cases. IV Severe staphylococcal infections >50 kg: 500 mg 3 times/day; <50 kg: 6-7 mg/kg 3 times/day. Topical Skin infections As 2% oint/cream/gel: Apply 3-4 times/day.
Dosage Details
Intravenous
Susceptible infections
Adult: >50 kg: 500 mg tid; may increase to 1 g tid in fulminating infections. <50 kg: 6-7 mg/kg tid. To be given by slow IV infusion over at least 2 hr; should be given via a large vein with good blood flow.
Child: 20 mg/kg daily in 3 divided doses. To be given by slow IV infusion over at least 2 hr; should be given via a large vein with good blood flow.

Ophthalmic
Conjunctivitis
Adult: As 1% eye drops: Instill 1 drop into the affected eye every 12 hr for 7 days.
Child: ≥2 yr: As 1% eye drops: Instill 1 drop into the affected eye every 12 hr for 7 days.

Oral
Susceptible infections
Adult: 500 mg tid. May increase to 1 g tid in severe infections.
Child: <1 year 6mg/kg; 1-5 years 250 mg; 5-12 years 500 mg; >12 years Same as adult dose. Doses to be taken tid.

Topical/Cutaneous
Skin infections
Adult: As a 2% ointment/cream/gel: Apply onto affected area 3-4 times daily until there is improvement. If gauze dressing is used, then frequency of application may be reduced to 1-2 times daily.
Child: As a 2% ointment/cream/gel: Apply onto affected area 3-4 times daily until there is improvement. If gauze dressing is used, then frequency of application may be reduced to 1-2 times daily.
Administration
Should be taken with food.
Reconstitution
Intravenous:
Each 500 mg dose is given as a buffered solution (pH 7.4-7.6) diluted to 500 ml with sodium chloride or other suitable IV solution.
Incompatibility
Intravenous:
Incompatible with amino acid solutions or whole blood. Admixture incompatibility: Carbenicillin, kanamycin, gentamicin, calcium solutions.
Contraindications
Hypersensitivity.
Special Precautions
Hepatic disease; monitor liver function. Neonates; pregnancy, lactation.
Adverse Reactions
Jaundice and liver dysfunction (reversible); GI disturbances. IV: Venospasm, thrombophloebitis and haemolysis; hypocalcaemia. SC/IM: Tissue necrosis. Topical: Rashes and irritation.
Drug Interactions
Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.
Food Interaction
Delays absorption for oral preparations.
Action
Description: Fusidic acid disrupts translocation of peptide subunits and elongating the peptide chain of susceptible bacteria, thus inhibiting protein synthesis.
Pharmacokinetics:
Absorption: Well-absorbed from the GI tract (oral); mean plasma concentrations of 30 mcg/ml after 2-4 hr (500-mg dose). More rapid absorption in children than in adults.
Distribution: Widely distributed into tissues and body fluids including bone, pus and synovial fluid; crosses the placenta and enters breast milk. Protein-binding: 95%.
Metabolism: Hepatic; converted to multiple metabolites.
Excretion: Bile (mainly as metabolites), faeces (2% as unchanged drug), urine; 5-6 hr (elimination half-life).
Storage
Intravenous:
Store below 25°C.
Ophthalmic:
Store between 2-25°C. Discard 1 mth after opening.
Oral:
Store below 25°C.
Topical/Cutaneous:
Store below 25°C.
Disclaimer: This information is independently developed by MIMS based on Fusidic acid from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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