Gadopentetic acid

Generic Medicine Info
Indications and Dosage
Cranial, spinal and whole body imaging
Adult: As gadopentetate dimeglumine: 0.1 mmol/kg (0.2 mL/kg), given at a rate not exceeding 10 mL/15 sec. If needed, an additional dose of 0.1-0.2 mmol/kg over 30 minutes may be given. Max: 0.3 mmol/kg.
Child: ≥1 month As gadopentetate dimeglumine: 0.1 mmol/kg (0.2 mL/kg), given at a rate not exceeding 10 mL/15 sec; >1 year If needed, additional dose of 0.1-0.2 mmol/kg over 30 minutes may be given.
Renal Impairment
Severe (GFR <30 mL/min/1.73 m2): Contraindicated.
Hypersensitivity. Acute kidney injury, patient in perioperative liver transplantation period. Severe renal impairment (GFR <30 mL/min/1.73 m2). Neonates <4 week.
Special Precautions
Patient with history of allergic reactions, bronchial asthma, seizure disorders, intracranial lesions. Mild to moderate renal impairment. Children. Pregnancy and lactation.
Adverse Reactions
Significant: Gadolinium retention, extravasation reactions (e.g. thrombosis, skin and soft tissue necrosis). Rarely, seizures.
Gastrointestinal disorders: Nausea, vomiting, dysgeusia.
Injury, poisoning and procedural complications: Inj site reactions (e.g. pain, oedema, irritation).
Nervous system disorders: Headache, dizziness.
Skin and subcutaneous tissue disorders: Hot or cold sensation.
Potentially Fatal: Nephrogenic systemic fibrosis. Rarely, hypersensitivity (e.g. anaphylactic reactions).
Monitoring Parameters
Monitor renal function prior to administration. Monitor for signs and symptoms of hypersensitivity reactions, extravasation, nephrogenic systemic fibrosis (e.g. muscle weakness, rib bone pain).
Lab Interference
Falsely low value result with serum Fe determination test using complexometric methods.
Description: Gadopentetic acid is an ionic gadolimium chelate, paramagnetic contrast media for MRI. It shortens the relaxation time of water protons in the plasma leading to increase in signal intensity, thus enhancing the image contrast between tissues.
Distribution: Rapidly distributed into the extracellular space. Crosses placenta and enters breast milk in small amount. Volume of distribution: Approx 0.266 ± 0.043 L/kg.
Excretion: Via urine (approx 91% as gadopentetate). Elimination half-life: 1.6 ± 0.13 hr.
Chemical Structure

Chemical Structure Image
Gadopentetic acid

Source: National Center for Biotechnology Information. PubChem Database. Gadopentetate, CID=6857474, (accessed on Jan. 22, 2020)

Store between 15-30°C. Do not freeze. Protect from light.
MIMS Class
Radiographic & Diagnostic Agents
ATC Classification
V08CA01 - gadopentetic acid ; Belongs to the class of paramagnetic agents used as magnetic resonance imaging contrast media.
Anon. Gadopentetate Dimeglumine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 05/01/2018.

Buckingham R (ed). Gadopentetic Acid. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 05/01/2018.

Magnevist Injection (Bayer HealthCare Pharmaceuticals Inc.). DailyMed. Source: U.S. National Library of Medicine. Accessed 05/01/2018.

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