Vildagliptin: Increased risk of angioedema w/ ACE inhibitors. Reduced hypoglycaemic effect w/ thiazides, corticosteroids, thyroid products & sympathomimetics. Metformin: Increased risk of lactic acidosis in acute alcohol intoxication, NSAIDs including selective COX-2 inhibitors, ACE inhibitors, AIIA, loop diuretics. Intrinsic hyperglycaemic activity w/ glucocorticoids, β2
-agonists & diuretics. Increased systemic exposure w/ organic cationic transporter-2 (OCT2)/multidrug & toxin extrusion (MATE) inhibitors (eg, ranolazine, vandetanib, dolutegravir and cimetidine). Decreased blood glucose levels w/ ACE inhibitors.