Hypersensitivity to the active substances or to any of the excipients.
Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis).
Severely reduced kidney function (GFR < 30 ml/min) (see PRECAUTIONS).
Acute conditions with the potential to alter renal function, such as: Dehydration; Severe infection; Shock; Intravascular administration of iodinated contrast agents (see PRECAUTIONS).
Acute or chronic disease which may cause tissue hypoxia, such as: Cardiac or respiratory failure; Recent myocardial infarction; Shock.
Hepatic impairment (see DOSAGE & ADMINISTRATION, PRECAUTIONS and ADVERSE REACTIONS).
Acute alcohol intoxication, alcoholism.
Breast-feeding (see USE IN PREGNANCY & LACTATION).